Taltz

Ixekizumab (Taltz®)

In case you’re on the fence about taking Taltz, here is some case study statistics for you to read. Taltz has no black box warnings. They also approved the drug for children over six years of age. I was on Taltz and I found it extremely effective. At the time it was painful to inject. They now make it without the citrate as a preservative, so the medication is painless to take. Overall I rate this drug a 9 out of 10 only because I got 4 years of use rather than 5. The content below is cited by NCBI.

“Ixekizumab is a high-affinity, humanized IgG4 monoclonal antibody for IL-17A, inhibiting interaction with the IL-17 receptor. FDA indications for ixekizumab include plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. The loading dose is 160 mg SC at week 0 and subsequent doses of 80 mg at weeks 2, 4, 6, 8, 10, and 12. Maintenance dosing is continued at 80 mg SC every 4 weeks. To maintain response to treatment, practitioners can consider increasing the dosing regimen to 80 mg SC every 2 weeks. It is the only biologic with data and FDA labeling specifically for genital plaque psoriasis. Also, ixekizumab is the only IL-17 agent that is FDA approved for treatment of plaque psoriasis down to the age of 6 years old. Ixekizumab was shown to be superior to placebo in the treatment of moderate‐to‐severe pediatric psoriasis, and the safety profile was generally consistent with that observed in adults.

Ixekizumab has very high efficacy as demonstrated through a PASI 75 achievement in 90% of patients by week 12. Efficacy data points to ixekizumab as being the fastest acting biologic. Head-to-head comparison showed a faster onset of action than guselkumab in the treatment of plaque psoriasis In head-to-head studies against adalimumab for treatment of psoriatic arthritis, both biologics were found to have similar symptom control and inhibition of joint destruction and bone erosion. Additionally, when both PASI 100 rates and psoriatic arthritis improvement results were combined, ixekizumab was superior to adalimumab.

Head-to-head comparison showed faster onset of action for ixekizumab vs guselkumab in the treatment of plaque psoriasis. The red box indicates the primary endpoint for the study. Notes:Reproduced from Blauvelt et. al. Ixekizumab vs. Guselkuamb: …

Ixekizumab is a well-tolerated biologic with minimal adverse events. It has no black box safety warnings and no evidence of increased tuberculosis risk. Of note, there is a higher rate of injection site pain and reaction, but during phase III studies 97% of patients with a reaction did not find it significant enough to discontinue the study. Injection site reaction was actually noted to improve over the course of treatment. There is also a concern of increased risk of IBD, however, the incidence of new-onset IBD is less than 1 out of 1000 patients on ixekizumab. Studies showed a slight increase in superficial fungal and yeast infections, although the candida rate in phase III studies is still less than 0.6% while on the once every 4 weeks dosing regimen versus 0.5% on placebo.”

Cosentyx

Getting Cozy with Cosentyx. Here is the information about the drug according to NCBI.

Secukinumab (Cosentyx®)

Secukinumab is a fully human G1k monoclonal antibody, which selectively binds and inhibits IL-17A. It is currently FDA approved for plaque psoriasis, ankylosing spondylitis, psoriatic arthritis, and active non-radiographic axial spondyloarthritis. Dosing of secukinumab for the treatment of psoriasis starts with a loading dose of 300 mg given SC at weeks 0, 1, 2, 3, and 4, followed by a maintenance dose of 300 mg SC every 4 weeks. In patients with lower body weight and minimal disease severity, 150 mg may be acceptable for maintenance dosing. For patients who may need higher doses, such as those with resistant disease and/or higher BMI, published data show a possible benefit of increasing dosing of secukinumab to 300mg SC every 2 weeks during maintenance. Higher dosing resulted in numerically superior efficacy, but due to size of the study, the difference was not statistically significant.

Secukinumab has excellent efficacy in the treatment of several disease domains. Dedicated studies for difficult to treat areas such as scalp, nail and palmoplantar psoriasis have been completed with data showing sustained efficacy for greater than 2 years for the latter two conditions. Secukinumab possesses higher efficacy versus several other subcutaneous biologic agents, showing superiority in head-to-head trials against both etanercept and ustekinumab. It also is the only biologic with a study showing efficacy for the treatment of axial psoriatic arthritis. Additionally, it has been recognized by the FDA for its efficacy in inhibiting psoriatic joint destruction, making it a better choice vs. an IL-23 or IL 12/23 agent for the treatment of psoriatic arthritis.
Clear skin responses (PASI 100) was greater among secukinumab treated patients compared to ustekinumab at every time point from week 4 out to week 16 in the CLARITY study.
Along with its exceptional clinical efficacy, it also has an extremely high recapture rate. After abrupt discontinuation of the drug and subsequent flare, restarting secukinumab led to 95% of patients achieving PASI 75 by week 12.

Secukinumab has the longest track record for safety in real-world usage out of all the IL-17 inhibitors and no black box safety warnings. It is one of the best tolerated biologic injectables in terms of injection site reactions and pain. While there is an already established association of increased re-activation and onset of tuberculosis risk in some biologics, particularly with TNF-alpha inhibitors, no study to date has found evidence of an increased tuberculosis risk in secukinumab.

There are very few adverse reactions of concern associated with secukinumab. Patients using secukinumab were found to have a mild increase in superficial fungal and yeast infections. Fungal rates in a phase III study for secukinumab, while increased over placebo, were less than 1%. Mucocutaneous candidiasis in the secukinumab treatment group was 1.2% vs. 0.3% placebo. Additionally, studies show an increased risk of inflammatory bowel disease (IBD); however, the incidence of new-onset IBD is less than 1 out of 1000 patients on secukinumab.

Overcoming Psoriasis has several drug specific groups and pages. For a more intimate experience about this medication I suggest you join our group(s) on Facebook. The medication support group for this specific medication is called Cosentyx support group. Thank you in advance for being a member. We strive to get you the most accurate and latest information possible.

#psoriasis #psoriaticarthritis

Fun times even with Psoriasis

List five things you do for fun.

1. I go for a relaxing walk to enjoy the scenery outdoors. Probably the best thing you can do for yourself and your health. Helps get everything flowing and reduces stress. Keeps you limber and fit. Good time to collect yourself and prepare for the next day. This low impact exercise strengthens the back muscles around the spine which helps those of us with spondylitis and psoriatic arthritis.

2. I like to go for a long bike rides and discover trails in hopes to see some wildlife. Once in awhile we will see mule deer and coyotes. There are plenty of rabbits and lizards in this area. I haven’t seen any rattlesnakes, mountain lions, or longhorn sheep. I have seen Bald Eagles and Road Runners. We also have lots of Quail. This is “God’s Country” for sure. Biking is one of the best low impact exercises you can do. Just be careful not to get hurt. I wouldn’t recommend it if your balance isn’t so good. Another way I control my autoimmune disease. Plus it’s a whole lot of fun especially if you ride with your family and friends.

3. I love going out on our side by side and seeing the inactive volcanoes and the beautiful blue water of the areas water reservoirs. I never knew how comfortable these UTV’s are when your out riding on the trails. They look intimidating but the shocks on this bad boy cushion most of the bumps. It’s not great exercise, but it will help produce adrenaline which is kinda the same outcome when you ride a roller coaster. Just no long lines before you get on. For me it’s a must do in anyone’s lifetime. A thrill seekers dream.

4. We love taking long drive’s especially when we travel to Wyoming and visit Jackson Hole. So many elk wondering about. We took advantage of the warm weather and managed to do some white water rafting. What a wonderful experience. We also were lucky to see a heard of Bison which I learned is the correct terminology for them in the USA. Jackson hole is a great ski resort. Vacationers hot spot.

5. It’s always fun to travel and see family around the holidays. It’s hectic flying these days, but it’s worth it when we get there and enjoy all the home cook meals. Traveling to a warm destination in the winter is always fun too. I prefer the warm weather, it’s better for my joints and skin. Plus the sun provides you with the much needed vitamin D. Most psoriasis patients are deficient in vitamin d. Safe travels! I hope this was an enjoyable read for you. Overcoming Psoriasis is possible when you learn how to tackle it on a daily basis.

#psoriasis #psoriaticarthritis #overcomingpsoriasis

Celebrities Living With Psoriasis, From Jonathan Van Ness to Cyndi Lauper

Psoriasis, a chronic autoimmune disease that causes red, scaly skin, affects 7.5 million Americans. Here are celebrities who live with the skin condition. Living with psoriasis—the chronic autoimmune disease that causes scaly, red, and inflamed skin—isn’t easy, but it helps to know that there are plenty of people out there, celebs included, who are dealing with the same frustrations and struggles.
— Read on www.yahoo.com/lifestyle/celebrities-living-psoriasis-jonathan-van-151200611.html

VTAMA by Dermavant Review

VTAMA (tapinarof) is a non-steroid prescription cream by Dermavant. FDA approved for psoriasis in May of 2022. Also seeking approval for Atopic Dermatitis in the near future. Tapinarof works by supporting the skin barrier proteins on the surface of the skin. Tapinarof increases the antioxidant activity while decreasing the oxidative stress levels in your skin. The active ingredient in VTAMA helps fix the imbalance in your immune system by supporting the Aryl hydrocarbon Receptor (AhR).

Most of us with Psoriasis would agree when the doctor prescribes another topical prescription we would roll our eyes. Because we know it’s not going to work, and if it does work after prolong use it makes matters worse. Well I’m here to tell you from my experience this prescription medication VTAMA, has been delightful. It has always been my mission as an advocate to inform others about successful treatment options. This treatment is a 10 plus in my view. From my rating perspective it covers all the bases. It’s super safe and very effective. I only applied a little amount each day for about eight days and my spots disappeared. And they stayed that way after I stopped treatment. It’s been almost two months. You read that right. Now I’ve had psoriasis for over 30 years and no product has ever produce these results that fast with lasting results. And absolutely no side effects. It behooves you to ask your doctor about this wonderful new product made available to you by Dermavant.

Now you might be thinking I’m being sponsored by the company to say this, I’m Not! This has been my personal experience. I’m committed to our community and I will continue until there’s a cure. Psoriasis stole a large part of my peace, and this is my way of winning it back. Hope my experience helps you. #psoriasis

Non-Steroidal cream super effective for World Psoriasis Day 2022

The challenges of psoriasis just got much easier. Psoriasis is a relentless disease affecting 125 million people globally. Treatments developed over the recent years have been extremely successful. However acquiring them requires a lot of work.

A new drug just recently became available. It’s a prescription non-steroidal cream. I’ve tried it on a stubborn spot. It’s completely gone after only a few applications. I can’t believe my eyes. And here’s the best part, it’s totally safe and effective to use almost anywhere on the body. Ask your doctor about this new innovative medication. I think you will be surprised.

twitter.com/VTAMAcream/status/1584555171723591681

#psoriasis #WPD2022 #Dermavant

Join our support group Overcoming Psoriasis on Facebook http://www.Facebook.com/groups/psowhat

Psoriasis

Living in the shadows of life. Avoiding social situations and activities. Staying out of relationships. Never wearing dark clothes. Deep depression and low self esteem. Changing careers or even choosing unemployment all because we fear what others will think. It’s all very hard to understand if your not actually living with the disease.

Maybe you’re newly diagnosed or you’ve had this disease for years, some of those situations might be your reality. I’ve experienced all those feelings and more. Years ago I literally had to “hang up my hat”.

Former Fireman/EMT Lieutenant Hook & Ladder. Fireman of the year 1995

The good news now is that this situation can be avoided. Due to the fact that we have so many treatments available. I can only speak from my experience. Still to this day, there isn’t a cure for psoriasis. But there are new and FDA approved prescription medications that are safe and effective. I know from what I read in the many support groups I’ve started that people are very concerned with side effects. I’m well aware of these concerns. I educate myself about each medication before I consider using it in order to control my disease. Most of you are aware that these drugs have to go through vigorous clinical trials and be evaluated before they are approved for use to the general public. I’m hoping my testimony helps you decide to seek help from your dermatologist or rheumatologist.

I was diagnosed with psoriasis when I was 28, over 30 years ago. My psoriasis was relentless, it took over my entire body. I felt helpless and it got to the point I felt worthless. I was at the lowest point of my life. Nobody could say or do anything to make me feel better. My psoriasis consumed me. I had a family to support and things got so bad it turned out they had to support me. Not something I would wish on anybody.

Then by some miracle I got a phone call about a clinical trial. I asked what it was all about and they explained. I didn’t know what to think or to say. I really didn’t have a choice, my disease took over my life. I was miserable. So much pain and embarrassment. I elected to volunteer for one of the first trials using an immune suppressant drug.

Just because I had my back against the wall didn’t mean I didn’t do my homework. I’ve read that this form of treatment was very promising. I sign the paperwork and started the medication. For the first time in years after many failed treatments my psoriasis was under control. I was extremely excited. I thought for sure this was the answer. But before I could celebrate a year later they withdrew the medication due to serious consequences for four patients in the trial. I rebounded from head to toe. I was hospitalized.

But I wanted that control back. I knew it was achievable and so did the scientists. They never gave up, they knew they were onto something. And they were right. Thanks to science we now have several immune suppressant biological medications that work extremely well. The safety profiles are stellar and their efficacy are exceptional. What’s great about these medications is that they target a specific pathway of the disease leaving the immune system intact. The medication blocks that pathway preventing the progression of psoriasis and psoriatic arthritis.

Unfortunately for me these drugs came a little late to the game as far as my careers were concerned, but I’m not complaining cause I’m practically 100% better. If I was newly diagnosed I wouldn’t hesitate to seek professional help. But don’t take my word for it, join one of the many support groups I’ve started and listen to others that have chosen this path.

Severe Plaque psoriasis of my back on the left from several years ago. The image on the right is a current photo of me using prescription medications.

I just wanted to add that I also apply topicals both prescribed and over the counter. I am also somewhat active with fitness and I educated myself about nutrition. Essentially I believe you can achieve these results too. Psoriasis is a serious autoimmune disease and needs to be addressed. If left untreated it can cause irreversible damage. We are at greater risk for several life threatening diseases. I’m encouraging you to come out of the shadows and live your life to the fullest.

#psoriasis #psoriaticdisease #overcomingpsoriasis #psoriaticarthritis #overcomingpsoriasis #dermatologist #skin

Celebrating 10 years of Overcoming Psoriasis

Tony Crimmins, psoriasis patient and CEO of Abundant Natural Health, hosted this interview. We discussed my support group Overcoming Psoriasis. I would like to thank all the members who made our group a huge success. Much work went into this group over the years. I believe our success has to do with the willingness of the members to share their experiences. We can all learn something from each other. It’s a blessing for me to be part of this. Thank you all once again. Because of you I’m Overcoming Psoriasis!

Psoriasis Awareness Month 2021

August is Psoriasis Awareness Month and it’s also our 10 year anniversary here at Overcoming Psoriasis. I would like to thank all of you who have made this group a huge success. To celebrate please join me on my FB lives for 10 days starting on Monday. Some lucky members who participate will receive free Ocean Soothe products from Abundant Natural Health. Share an experience with me live and you are guaranteed a product.

Www.facebook.com/groups/psowhat

Why is Psoriasis Awareness Month so important to me? There are so many misconceptions about psoriasis. Over the years with huge efforts from the National Psoriasis Foundation, I feel more people are aware of our disease. More people know our disease isn’t contagious. More people know our disease is a serious autoimmune condition that goes beyond the skin. More people know Psoriasis is a genetic disease and once triggered it affects every aspect of your life. More people know there is no cure, only control. More people know it affects 2 to 3 percent of the population, roughly 125 million people. At least 7.5 million Americans suffer with psoriasis. More people know it’s the most prevalent autoimmune disease. More people know it affects the joints and organs too. More people know Psoriasis presents other circumstances that can be life threatening known as comorbidities. More people know it can affect the eyes as well. More people know it can be disabling. More people know depression is extremely common in our community. More people are Overcoming Psoriasis with our support group. Thank you to all our members, God Bless!
(((Hugs))) all around.

Taming Psoriasis and Psoriatic Arthritis

After years of suffering, I finally found a regimen that works.

Psoriasis can be a frustrating disease.  Psoriasis has been around forever, it’s a disease that dates back to biblical days.  This autoimmune disease affects 2-3 percent of the world population.  The National Psoriasis Foundation estimates around 125 million people suffer globally.  In the United States 7.5 million Americans are afflicted with this insidious disease.  There are so many misconceptions about our disease.  Let me just say this before we go on; “PSORIASIS IS NOT CONTAGIOUS” and “PSORIASIS IS MORE THAN SKIN DEEP”.

I was diagnosed with psoriasis at the age of 28.  I wanted to start a family with my wife at the time.  I was very concerned that my children would develop the disease.  Due to my research I discovered that my kids had a small percentage of developing the disease.  If one parent is genetically predisposed to psoriasis the odds of the child having the disease is only 3%.  If both parents have the genes the percentage increases to over 50%.  There is also some science that indicates psoriasis can skip generations.

If you have psoriasis I don’t have to tell you how painful, itchy, flakey, stubborn, relentless, depressing, tiring, aggravating, embarrassing, frustrating, resistant to treatment, completely misunderstood, visible, invisible, life altering this disease it can be.  I’m writing this blog to share with you my success.

I don’t want to bore you with past treatments.  I will only share with you what I’m currently using.  Trust me I’ve been on many treatments and I’ve tried just about everything. 

First and foremost, it behooves you to see a board certified dermatologist and rheumatologist.  Nothing what I say is to replace your doctors recommendations.  These are purely my experiences.  Everyone’s experiences will be different.   Just wanted to mention that as a disclaimer.

So let’s start with my number one reason for my success.   At this time I’m using a biological medication prescribed by my doctor called Taltz.  It’s made by Lilly pharmaceutical.  According to scientific data it’s safe and very effective.  Many patients that were in the clinical trials for the medication achieved 100% PASI score.

My routine also includes some form of exercise in order to help the bodies organ functions.  When I trained my travel soccer team as a coach I used interval training.  Interval exercises are very effective getting the body in shape in a short period of time. Without a lengthy explanation, it’s high intensity exercises followed by low intensity exercises. Rinse and repeat. Regular exercise can help the circulatory systems of the body.  Including the lymphatic system, blood circulatory system, nervous system, and the endocrine system.  I like to use low impact exercises so I don’t injure myself.  Exercises that are easy on the joints, tendons, and ligaments.  Walking, swimming, bike riding, resistance bands, light weights, hiking, calisthenics, stretching, and even beginners yoga. 

Climate therapy is often undervalued.  I try and get 30 minutes of sunshine per day.  I find this very important.  Most of us who suffer with autoimmune disease are vitamin D deficient.  Sunlight provides that vitamin and helps eliminate the symptoms of psoriasis.  Sun and sea can help change my moods as well.  Often while I’m on the beach my moods are lifted and I feel so much better.  Of course, there have been times when I was covered in psoriasis and I felt self conscious.  Vitamin sea is essential so regardless of how I felt, I needed to be out in the sun. Light box is another alternative. Tanning can also be substituted but the risk of skin cancer should be considered. Talk with your dermatologist for more suggestions.

So many of us struggle with diet. I assure you I struggle too.  But I developed life hacks that has helped me along the way.  Years ago I was a lawn care specialist and I applied some of those techniques to weed out my psoriasis.  Just like with a lawn we fertilize the grass in order to crowd out the weeds.  I use this technique with nutrition.  I use the 80/20 system in order to maintain my weight and control my cravings.  Arbonne has the best nutritional supplements.  They have been in business for over 40 years.  I believe their products help to reduce the inflammation throughout my body. Therefore reducing the symptoms of my disease. My daughter suggested I try Arbonne because she turned her weight gain around. She trimmed down using their products. She lost thirty pounds in three months. I’m extremely proud of her accomplishments.

When I was a Fireman/Emt we learned how to quickly size up the fire scene.  As an EMT I learned patient assessment.  I often used those learned techniques in order to help me battle my own fires or health conditions.  As a fireman in order to extinguish the flames we have to eliminate one of the three necessary elements of fire.  The easiest way to put out a fire is to reduce the heat by adding water.  Another way to put out a fire is to smother it by reducing the oxygen. The last part of the fire triangle is combustible material. So with that in mind, our disease is aggrevated by inflammatory foods,drink, and genetics.  I use the same principles of the fire service to reduce the symptoms of psoriasis.

Last but not least I have to give credit to Abundant Natural Health.  Their products are simply amazing.  They developed products for the many types of psoriasis including Psoriatic Arthritis.  I use them most everyday. Ocean Soothe gel and lotion contain natural ingredients and are available at: Www.abundantnaturalhealth.com

Good luck on your journey.  I find I have to be consistent with treatment.  If your having difficulty please reach out to me, I would be happy to help.  You can leave a comment below.  Psoriasis doesn’t define me and the definition will never consume me. You can be Overcoming Psoriasis too! Yours truly, Todd Bello

#psoriasis #OvercomingPsoriasis #psoriasiswarrior #psoriaticarthritis